{
  "_id": "6a117476acfb0bcc41cf883f",
  "Package": "DSAIRM",
  "Type": "Package",
  "Title": "Dynamical Systems Approach to Immune Response Modeling",
  "Description": "Simulation models (apps) of various within-host immune\nresponse scenarios. The purpose of the package is to help\nindividuals learn about within-host infection and immune\nresponse modeling from a dynamical systems perspective. All\napps include explanations of the underlying models and\ninstructions on what to do with the models.",
  "Version": "0.9.7",
  "Date": "2024-07-19",
  "Authors@R": "c(\nperson(\"Andreas\", \"Handel\", email = \"andreas.handel@gmail.com\", role = c(\"aut\", \"cre\"), comment = c(ORCID = \"0000-0002-4622-1146\") ),\nperson(\"Cody\", \"Dailey\",  role = \"ctb\"),\nperson(\"Yang\", \"Ge\",  role = \"ctb\"),\nperson(\"Spencer\", \"Hall\",  role = \"ctb\"),\nperson(\"Brian\", \"McKay\",  role = \"ctb\"),\nperson(\"Sina\", \"Solaimanpour\",  role = \"ctb\"),\nperson(\"Alexis\", \"Vittengl\",  role = \"ctb\"),\nperson(\"Henok\", \"Woldu\",  role = \"ctb\")\n)",
  "Maintainer": "Andreas Handel <andreas.handel@gmail.com>",
  "License": "GPL-3",
  "Encoding": "UTF-8",
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  "URL": "https://ahgroup.github.io/DSAIRM/,\nhttps://github.com/ahgroup/DSAIRM/",
  "BugReports": "https://github.com/ahgroup/DSAIRM/issues",
  "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev libxml2-dev\nlibssl-dev zlib1g-dev",
  "Repository": "https://ahgroup.r-universe.dev",
  "Date/Publication": "2024-07-19 15:51:13 UTC",
  "RemoteUrl": "https://github.com/ahgroup/dsairm",
  "RemoteRef": "HEAD",
  "RemoteSha": "62d9916da524af80569984b2cc384df9c83db563",
  "NeedsCompilation": "no",
  "Packaged": {
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    "User": "root"
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  "Author": "Andreas Handel [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-4622-1146>),\nCody Dailey [ctb],\nYang Ge [ctb],\nSpencer Hall [ctb],\nBrian McKay [ctb],\nSina Solaimanpour [ctb],\nAlexis Vittengl [ctb],\nHenok Woldu [ctb]",
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  "_published": "2026-05-23T09:33:42.813Z",
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  "_realowner": "ahgroup",
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    },
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    },
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    },
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    "check_simresults",
    "dsairmmenu",
    "generate_documentation",
    "generate_fctcall",
    "generate_ggplot",
    "generate_modelsettings",
    "generate_plotly",
    "generate_shinyinput",
    "generate_text",
    "run_model",
    "simulate_acutevirusir_ode",
    "simulate_bacteria_fit",
    "simulate_basicbacteria_discrete",
    "simulate_basicbacteria_modelexploration",
    "simulate_basicbacteria_ode",
    "simulate_basicvirus_fit",
    "simulate_basicvirus_modelexploration",
    "simulate_basicvirus_ode",
    "simulate_basicvirus_stochastic",
    "simulate_chronicvirusir_ode",
    "simulate_confint_fit",
    "simulate_drugresistance_stochastic",
    "simulate_extendedbacteria_ode",
    "simulate_fludrug_fit",
    "simulate_modelcomparison_fit",
    "simulate_modelvariants_ode",
    "simulate_pkpdmodel_ode",
    "simulate_usanalysis",
    "simulate_virusandir_ode",
    "simulate_virusandtx_ode"
  ],
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      "name": "hayden96flu",
      "title": "Influenza virus load data",
      "object": "hayden96flu",
      "class": [
        "data.frame"
      ],
      "fields": [
        "HoursPI",
        "txtime",
        "LogVirusLoad",
        "LOD"
      ],
      "rows": 27,
      "table": true,
      "tojson": true
    },
    {
      "name": "schirm20strep",
      "title": "Streptococcus pneumoniae infection data",
      "object": "schirm20strep",
      "class": [
        "data.frame"
      ],
      "fields": [
        "time",
        "value",
        "quantity"
      ],
      "rows": 99,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "check_simresults",
      "title": "A function that checks if a call to simulation function worked",
      "topics": [
        "check_simresults"
      ]
    },
    {
      "page": "dsairmmenu",
      "title": "The main menu for the DSAIRM package",
      "topics": [
        "dsairmmenu"
      ]
    },
    {
      "page": "generate_documentation",
      "title": "A helper function which processes and displays the documentation part for each app",
      "topics": [
        "generate_documentation"
      ]
    },
    {
      "page": "generate_fctcall",
      "title": "A helper function that produces a call to a simulator function for specific settings",
      "topics": [
        "generate_fctcall"
      ]
    },
    {
      "page": "generate_ggplot",
      "title": "A helper function that takes simulation results and produces ggplot plots",
      "topics": [
        "generate_ggplot"
      ]
    },
    {
      "page": "generate_modelsettings",
      "title": "A function to parse modelsettings for simulation runs",
      "topics": [
        "generate_modelsettings"
      ]
    },
    {
      "page": "generate_plotly",
      "title": "A helper function that takes simulation results and produces plotly plots",
      "topics": [
        "generate_plotly"
      ]
    },
    {
      "page": "generate_shinyinput",
      "title": "A helper function that takes a model and generates shiny UI elements",
      "topics": [
        "generate_shinyinput"
      ]
    },
    {
      "page": "generate_text",
      "title": "A helper function that takes result from the simulators and produces text output",
      "topics": [
        "generate_text"
      ]
    },
    {
      "page": "hayden96flu",
      "title": "Influenza virus load data",
      "topics": [
        "hayden96flu"
      ]
    },
    {
      "page": "run_model",
      "title": "A function that runs an app for specific settings and processes results for plot and text generation",
      "topics": [
        "run_model"
      ]
    },
    {
      "page": "schirm20strep",
      "title": "Streptococcus pneumoniae infection data",
      "topics": [
        "schirm20strep"
      ]
    },
    {
      "page": "simulate_acutevirusir_ode",
      "title": "Acute Virus Infection and IR Model",
      "topics": [
        "simulate_acutevirusir_ode"
      ]
    },
    {
      "page": "simulate_bacteria_fit",
      "title": "Fitting a simple bacteria infection models to Streptococcus pneumoniae infection data",
      "topics": [
        "simulate_bacteria_fit"
      ]
    },
    {
      "page": "simulate_basicbacteria_discrete",
      "title": "Basic Bacteria model - discrete",
      "topics": [
        "simulate_basicbacteria_discrete"
      ]
    },
    {
      "page": "simulate_basicbacteria_modelexploration",
      "title": "Simulation to illustrate parameter scan of the basic bacteria model #'",
      "topics": [
        "simulate_basicbacteria_modelexploration"
      ]
    },
    {
      "page": "simulate_basicbacteria_ode",
      "title": "Basic Bacteria model - ODE",
      "topics": [
        "simulate_basicbacteria_ode"
      ]
    },
    {
      "page": "simulate_basicvirus_fit",
      "title": "Fitting a simple viral infection models to influenza data",
      "topics": [
        "simulate_basicvirus_fit"
      ]
    },
    {
      "page": "simulate_basicvirus_modelexploration",
      "title": "Simulation to illustrate parameter scan of the basic virus model #'",
      "topics": [
        "simulate_basicvirus_modelexploration"
      ]
    },
    {
      "page": "simulate_basicvirus_ode",
      "title": "Basic Virus Model",
      "topics": [
        "simulate_basicvirus_ode"
      ]
    },
    {
      "page": "simulate_basicvirus_stochastic",
      "title": "Basic Virus Model",
      "topics": [
        "simulate_basicvirus_stochastic"
      ]
    },
    {
      "page": "simulate_chronicvirusir_ode",
      "title": "Chronic Virus Infection and IR Model",
      "topics": [
        "simulate_chronicvirusir_ode"
      ]
    },
    {
      "page": "simulate_confint_fit",
      "title": "Fit a simple viral infection model and compute confidence intervals",
      "topics": [
        "simulate_confint_fit"
      ]
    },
    {
      "page": "simulate_drugresistance_stochastic",
      "title": "Stochastic simulation of a compartmental acute virus infection model with treatment and drug resistant strain",
      "topics": [
        "simulate_drugresistance_stochastic"
      ]
    },
    {
      "page": "simulate_extendedbacteria_ode",
      "title": "Extended Bacteria model - ODE",
      "topics": [
        "simulate_extendedbacteria_ode"
      ]
    },
    {
      "page": "simulate_fludrug_fit",
      "title": "Fitting a simple viral infection model with 2 types of drug mechanisms to influenza data",
      "topics": [
        "simulate_fludrug_fit"
      ]
    },
    {
      "page": "simulate_modelcomparison_fit",
      "title": "Fitting 2 simple viral infection models to influenza data",
      "topics": [
        "simulate_modelcomparison_fit"
      ]
    },
    {
      "page": "simulate_modelvariants_ode",
      "title": "Simulation of a viral infection model with immune response The simulation illustrates different alternative models.",
      "topics": [
        "simulate_modelvariants_ode"
      ]
    },
    {
      "page": "simulate_pkpdmodel_ode",
      "title": "PkPd Virus model",
      "topics": [
        "simulate_pkpdmodel_ode"
      ]
    },
    {
      "page": "simulate_usanalysis",
      "title": "Simulation to illustrate uncertainty and sensitivity analysis",
      "topics": [
        "simulate_usanalysis"
      ]
    },
    {
      "page": "simulate_virusandir_ode",
      "title": "Simulation of a viral infection model with an immune response",
      "topics": [
        "simulate_virusandir_ode"
      ]
    },
    {
      "page": "simulate_virusandtx_ode",
      "title": "Simulation of a basic viral infection model with drug treatment",
      "topics": [
        "simulate_virusandtx_ode"
      ]
    }
  ],
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      "filename": "DSAIRM.html",
      "title": "DSAIRM Package Tutorial",
      "author": "Andreas Handel",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Package description",
        "Intended audience and goal of the package",
        "Installation",
        "Using the package through the graphical user interface (Level 1)",
        "Directly interacting with the simulation functions (Level 2)",
        "Modifying the simulation functions (Level 3)",
        "Contributing to the package",
        "Further information",
        "Contributors",
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        "References"
      ],
      "created": "2017-10-02 20:48:21",
      "modified": "2023-10-02 23:25:51",
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